Tos M, Bak-Pedersen K
Arch Otolaryngol. 1975 Feb;101(2):123-8. doi: 10.1001/archotol.1975.00780310045013.
Histopathological study of the earliest stage of secretory otitis was made in a 3-month-old infant. The entire mucosa was examined by the whole-mount method, with determination of gland count and goblet-cell density, followed by assessment of serial sections. The first changes are inflammatory with lymphocytic infiltration, dilatation, and increase of blood vessels. These again induce metaplasia into pseudostratified, ciliated epithelium, increased in goblet-cell density, and formation of intraepithelial and subepithelial mucous glands. Basal cells divide and grow down into lamina propria, giving rise to a solid cylinder that gets canalized. Cells of this cylinder differentiate into ciliated and mucous cells, so that tubules acquire a lining of typical pseudostratified, ciliated, columnar epithelium. The most important processes in the early stage of secretory otitis are hyperplasia, differentiation of epithelial cells, and gland formation. When glands have completed their development, they produce mucus that accumulates in the middle ear, and the disease enters the secretory stage.
对一名3个月大婴儿分泌性中耳炎最早阶段进行了组织病理学研究。采用整装法检查整个黏膜，确定腺体数量和杯状细胞密度，随后评估连续切片。最初的变化是炎症性的，伴有淋巴细胞浸润、血管扩张和增多。这些变化又会导致化生为假复层纤毛上皮，杯状细胞密度增加，以及上皮内和上皮下黏液腺形成。基底细胞分裂并向下生长进入固有层，形成一个实心圆柱体，随后管道化。这个圆柱体的细胞分化为纤毛细胞和黏液细胞，使小管获得典型的假复层纤毛柱状上皮内衬。分泌性中耳炎早期最重要的过程是上皮细胞增生、分化和腺体形成。当腺体发育完成后，它们会产生积聚在中耳的黏液，疾病进入分泌期。
