Okada H, Tajima T, Kawahara M, Rikihisa Y
Department of Veterinary Pathology, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
J Comp Pathol. 2001 Feb-Apr;124(2-3):165-71. doi: 10.1053/jcpa.2000.0447.
Ehrlichia chaffeensis, the agent of human monocytic ehrlichiosis, is closely related to the HF strain of Ehrlichia isolated from ticks in Japan. In this study, BALB/c mice inoculated intraperitoneally with the HF strain developed severe illness and died at about day 9 post-inoculation. At necropsy, diffuse liver necrosis was evident. Ehrlichial microcolonies were observed in endothelial cells, monocytes and macrophages of the liver, bone marrow, spleen, thymus, and large and small intestine. Immunocompetent mice infected with the HF strain would provide a useful model for studying pathogenesis and immunity in acute and severe ehrlichiosis caused by E. chaffeensis and related Ehrlichia spp.
查菲埃立克体是人类单核细胞埃立克体病的病原体，与从日本蜱虫中分离出的埃立克体HF株密切相关。在本研究中，经腹腔接种HF株的BALB/c小鼠出现严重病症，并在接种后约第9天死亡。尸检时，可见弥漫性肝坏死。在肝脏、骨髓、脾脏、胸腺以及大小肠的内皮细胞、单核细胞和巨噬细胞中观察到埃立克体微菌落。感染HF株的免疫活性小鼠将为研究查菲埃立克体及相关埃立克体属引起的急性和严重埃立克体病的发病机制和免疫提供一个有用的模型。
