Arnez M, Petrovec M, Lotric-Furlan S, Zupanc T A, Strle F
Department of Infectious Diseases, University Medical Center Ljubljana, Japljeva 2, 1525 Ljubljana, Slovenia.
J Clin Microbiol. 2001 Dec;39(12):4591-2. doi: 10.1128/JCM.39.12.4591-4592.2001.
Herein we report on the first confirmed pediatric case of acute human granulocytic ehrlichiosis in Europe. Presentation in this 11-year-old girl was comparable to clinical findings seen in adult European patients with human granulocytic ehrlichiosis; i.e., she had self-limited febrile illness with leukopenia, thrombocytopenia, and elevated serum C-reactive protein concentration. It is of interest that the patient not only had a fourfold change in antibody titer to Ehrlichia phagocytophila but also developed antibodies to Ehrlichia chaffeensis and that her PCR test result was positive on the third as well as on the 22nd day after the onset of illness, that is, 16 days after spontaneous defervescence.
在此,我们报告欧洲首例确诊的儿童急性人粒细胞埃立克体病病例。这位11岁女孩的临床表现与欧洲成人粒细胞埃立克体病患者的临床发现相似;即她患有自限性发热疾病,伴有白细胞减少、血小板减少和血清C反应蛋白浓度升高。值得注意的是,该患者不仅对嗜吞噬细胞埃立克体的抗体滴度有四倍变化,还产生了针对查菲埃立克体的抗体,并且她的PCR检测结果在发病后第3天和第22天呈阳性,即在自发退热16天后。