Lightbody J H, Stevenson L M, Jackson F, Donaldson K, Jones D G
Napier University, 10 Colinton Road, Edinburgh EH10 5DT, Scotland, UK.
J Comp Pathol. 2001 Feb-Apr;124(2-3):192-9. doi: 10.1053/jcpa.2000.0453.
This paper provides, for the first time, comparative data on the plasma antioxidant status of two ruminant species, namely sheep and goats. In addition, the influence of experimental infection with Teladorsagia circumcincta on antioxidant status in the same two species is compared and contrasted. In general terms, antioxidant status was significantly higher in uninfected kids than in lambs. Differences in protein sulphydryl groups and vitamin E concentrations were particularly noteworthy; trends were similar, however, for albumin, vitamin A and total antioxidant capacity (TAC). Parasitological results, based on worm burden, faecal egg counts and peripheral blood eosinophil numbers, confirmed that goat kids were more susceptible than lambs to experimental T. circumcincta infection. "Trickle infection" had a variable impact on both total and individual antioxidant status; particularly during the early weeks, the trend was for reduced values in lambs and increased values in kids, as compared with uninfected controls. Subsequent challenge infection was associated with a transient decrease in TAC and albumin in trickle-infected animals of both species, and in appropriate control animals. The observed differences in plasma antioxidant capacity between sheep and goats may have important implications in terms of the comparative resilience of sheep and goats to parasite infection.
本文首次提供了两种反刍动物，即绵羊和山羊血浆抗氧化状态的比较数据。此外，还比较和对比了环形泰勒虫实验感染对这两种动物抗氧化状态的影响。总体而言，未感染的山羊羔的抗氧化状态显著高于羔羊。蛋白质巯基和维生素E浓度的差异尤为显著；然而，白蛋白、维生素A和总抗氧化能力（TAC）的趋势相似。基于虫负荷、粪便虫卵计数和外周血嗜酸性粒细胞数量的寄生虫学结果证实，山羊羔比羔羊更容易受到环形泰勒虫实验感染。“微量感染”对总抗氧化状态和个体抗氧化状态都有不同的影响；特别是在最初几周，与未感染的对照组相比，羔羊的数值呈下降趋势，而山羊羔的数值呈上升趋势。随后的激发感染与两种动物的微量感染动物以及适当的对照动物的TAC和白蛋白短暂下降有关。绵羊和山羊血浆抗氧化能力的差异可能对绵羊和山羊对寄生虫感染的相对恢复力具有重要意义。
