Pérez J, García P M, Mozos E, Bautista M J, Carrasco L
Department of Comparative Pathology, Faculty of Veterinary Medicine, Campus de Rabinales, University of Córdoba, Ctra. Madrid-Cadiz, Km 396, 14014 Córdoba, Spain.
J Comp Pathol. 2001 Feb-Apr;124(2-3):200-6. doi: 10.1053/jcpa.2000.0455.
This paper describes the histopathological features and the cellular distribution of T lymphocytes (CD3), B cells (CD79a), immunoglobulin (IgG, IgA, IgM)-bearing plasma cells, macrophages (Mac387 and alpha-1-antitrypsin), MHC class II antigen and S-100 protein in hepatic white spots associated with naturally occurring Ascaris suum parasitism in 35 pigs. Hepatic granulomas were observed in 10 pigs, whereas lymphoid proliferation with a diffuse or lymphonodular pattern was the main histopathological lesion in 14 other pigs, and portal fibrosis in a further 11 animals. In lymphonodular lesions, the distribution of immunoreactive cells with all antibodies tested was closely similar to that found in the cortex of lymph nodes. Thus, lymphoid follicles were composed mainly of CD79a(+)B cells and interfollicular tissue was composed mainly of CD3(+)T lymphocytes. The presence of follicular dendritic and interdigitating cells expressing S-100 protein and MHC class II antigen in lymphonodular lesions suggested that these are highly organized structures developed to enhance antigen presentation to B and T cells, and consequently the local immune response against the parasite. The humoral local response was represented mainly by IgG-secreting plasma cells.
本文描述了35头自然感染猪蛔虫的猪肝脏白斑中T淋巴细胞（CD3）、B细胞（CD79a）、携带免疫球蛋白（IgG、IgA、IgM）的浆细胞、巨噬细胞（Mac387和α-1抗胰蛋白酶）、MHC II类抗原和S-100蛋白的组织病理学特征及细胞分布。10头猪观察到肝脏肉芽肿，而另外14头猪主要的组织病理学病变为弥漫性或淋巴小结样的淋巴样增生，另有11头动物出现门脉纤维化。在淋巴小结样病变中，所有检测抗体的免疫反应性细胞分布与淋巴结皮质中的情况极为相似。因此，淋巴滤泡主要由CD79a(+)B细胞组成，滤泡间组织主要由CD3(+)T淋巴细胞组成。淋巴小结样病变中表达S-100蛋白和MHC II类抗原的滤泡树突状细胞和交错突细胞的存在表明，这些是为增强向B细胞和T细胞的抗原呈递以及因此增强针对寄生虫的局部免疫反应而形成的高度有组织的结构。局部体液反应主要由分泌IgG的浆细胞代表。
