[静脉注射大环内酯类抗生素所致静脉炎。红霉素与克拉霉素的对比研究]
[Phlebitis due to intravenous administration of macrolide antibiotics. A comparative study of erythromycin versus clarithromycin].
作者信息
de Dios García-Díaz J, Santolaya Perrín R, Paz Martínez Ortega M, Moreno-Vázquez M
机构信息
Medicina Interna, Hospital Universitario Príncipe de Asturias, Universidad de Alcalá, Alcalá de Henares, Madrid.
出版信息
Med Clin (Barc). 2001 Feb 3;116(4):133-5. doi: 10.1016/s0025-7753(01)71748-4.
BACKGROUND
To know and to compare the incidence of phlebitis due to intravenous administration of macrolide antibiotics erythromycin and clarithromycin.
PATIENTS AND METHOD
Non-randomized prospective study of consecutive patients who were diagnosed of community pneumonia and treated with intravenous macrolides (19 with erythromycin and 25 with clarithromycin).
RESULTS
The cumulative incidence of phlebitis in patients treated with erythromycin was 78.9% (incidence rate of 0.40 episodes/patient-day) and in those treated with clarithromycin 76% (incidence rate of 0.35 episodes/patient-day).
CONCLUSIONS
The risk of phlebitis is high and similar with intravenous administration of both macrolides.
背景
了解并比较静脉注射大环内酯类抗生素红霉素和克拉霉素所致静脉炎的发生率。
患者与方法
对连续诊断为社区肺炎并接受静脉大环内酯类药物治疗的患者进行非随机前瞻性研究（19例使用红霉素，25例使用克拉霉素）。
结果
接受红霉素治疗的患者静脉炎累积发生率为78.9%（发生率为0.40例/患者日），接受克拉霉素治疗的患者为76%（发生率为0.35例/患者日）。
结论
两种大环内酯类药物静脉注射时静脉炎风险均较高且相似。
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