Paulini K, Beneke G, Körner B, Enders R
Beitr Pathol. 1975;154(2):161-9. doi: 10.1016/s0005-8165(75)80209-5.
Either porous polyester-polyurethane cylindrical sponges with a diameter of 12 mm (thickness 6 mm) or rectangular sponges (dimensions 120 times 20 times 5 mm) were implanted paravertebrally in the subcutis of a total of 118 rats of different ages (1-15 1/2 months). It was established that the rate of tumor formation increased with the size of the implant from 12.1% (cylindrical sponges) to 26.6% (rectangular sponges). Furthermore is could be shown that in animal experiments it is the age of the rats that plays the decisive role in sarcogenesis and not the latend period (time from the implantation until development of the tumor), in that young animals first develop malignant mesenchymal tumors after a mean 17.2 months whereas in old rats these had already developed after 6.3 months.
将直径12毫米（厚度6毫米）的多孔聚酯 - 聚氨酯圆柱形海绵或矩形海绵（尺寸为120×20×5毫米）植入总共118只不同年龄（1至15个半月）大鼠的皮下椎旁区域。结果发现，肿瘤形成率随着植入物尺寸的增加而升高，从12.1%（圆柱形海绵）升至26.6%（矩形海绵）。此外，可以证明在动物实验中，大鼠的年龄在肉瘤形成中起决定性作用，而非潜伏期（从植入到肿瘤出现的时间），因为幼年动物平均在17.2个月后才首次出现恶性间充质肿瘤，而老年大鼠在6.3个月后就已出现。
