O'Keefe M, Kafil-Hussain N, Flitcroft I, Lanigan B
Br J Ophthalmol. 2001 Mar;85(3):357-9. doi: 10.1136/bjo.85.3.357.
To document ocular outcome in premature infants with intraventricular haemorrhages (IVH).
68 preterm infants with IVH were examined.
Mean gestational age was 28.1 weeks (range 24-35). Mean birth weight was 1045.9 g (630-2240). Mean follow up was 54.6 months (6-150). IVH is graded from 1 to 4 based on the severity of haemorrhages. The incidence of ocular abnormalities was compared between low grade IVH (grade 1 and 2) and high grade IVH (grade 3 and 4). Of the 68 infants with IVH, ROP occurred in 33 infants (48.5%); 13 (43.3%) had low grade IVH; 20 (52.6%) had high grade IVH. Strabismus developed in 30 infants (44.1%); 14 (46.6%) had low grade IVH; 16 (42.1%) had high grade IVH. Infants with high grade IVH were at significant greater risk than infants with low grade IVH for the development of optic atrophy (31.5% v 16.6%), hydrocephalus (57.8% v 10%).
This study highlights the serious significance of all grades of IVH with the higher incidence of optic atrophy and hydrocephalus with high grade IVH.
记录脑室出血（IVH）早产儿的眼部预后情况。
对68例患有IVH的早产儿进行检查。
平均胎龄为28.1周（范围24 - 35周）。平均出生体重为1045.9克（630 - 2240克）。平均随访时间为54.6个月（6 - 150个月）。IVH根据出血严重程度分为1至4级。比较了低级别IVH（1级和2级）和高级别IVH（3级和4级）患儿眼部异常的发生率。在68例患有IVH的婴儿中，33例（48.5%）发生了视网膜病变；其中13例（43.3%）为低级别IVH；20例（52.6%）为高级别IVH。30例（44.1%）出现斜视；其中14例（46.6%）为低级别IVH；16例（42.1%）为高级别IVH。高级别IVH患儿发生视神经萎缩（31.5%对16.6%）和脑积水（57.8%对10%）的风险显著高于低级别IVH患儿。
本研究强调了各级IVH的严重意义，高级别IVH时视神经萎缩和脑积水的发生率更高。
