脑血流量低是严重脑室内出血的一个危险因素。
Low cerebral blood flow is a risk factor for severe intraventricular haemorrhage.
作者信息
Meek J H, Tyszczuk L, Elwell C E, Wyatt J S
机构信息
Department of Paediatrics University College London Medical School WC1E 6JJ, UK.
出版信息
Arch Dis Child Fetal Neonatal Ed. 1999 Jul;81(1):F15-8. doi: 10.1136/fn.81.1.f15.
AIMS
To investigate the relation between cerebral blood flow on the first day of postnatal life and the severity of any subsequent germinal matrix haemorrhage-intraventricular haemorrhage (GMH-IVH).
METHODS
Cerebral blood flow was measured in 24 babies during the first 24 hours of life using near infrared spectroscopy. Repeated cerebral ultrasound examination was performed to define the maximum extent of GMH-IVH. Infants were classified as: normal scan, minor periventricular haemorrhage (haemorrhage that resolved), or severe GMH-IVH (haemorrhage distending the ventricles, that progressed to either post haemorrhagic dilatation or porencephalic cyst formation).
RESULTS
Cerebral blood flow was significantly lower in the infants with GMH-IVH (median 7.0 ml/100 g/min) than those without haemorrhage (median 12.2 ml/100 g/min), despite no difference in carbon dioxide tension and a higher mean arterial blood pressure. On subgroup analysis, those infants with severe GMH-IVH had the lowest cerebral blood flow.
CONCLUSION
A low cerebral blood flow on the first day of life is associated with the subsequent development of severe intraventricular haemorrhage.
目的
研究出生后第一天脑血流量与随后生发基质出血-脑室内出血（GMH-IVH）严重程度之间的关系。
方法
使用近红外光谱法在24例婴儿出生后的头24小时内测量脑血流量。进行多次脑部超声检查以确定GMH-IVH的最大范围。婴儿被分为：扫描正常、轻度脑室周围出血（出血自行吸收）或重度GMH-IVH（出血使脑室扩张，进展为出血后扩张或脑穿通畸形囊肿形成）。
结果
GMH-IVH婴儿的脑血流量（中位数7.0毫升/100克/分钟）显著低于无出血婴儿（中位数12.2毫升/100克/分钟），尽管二氧化碳分压无差异且平均动脉血压较高。亚组分析显示，重度GMH-IVH婴儿的脑血流量最低。
结论
出生第一天脑血流量低与随后严重脑室内出血的发生有关。
Zotero 插件