Vogelsang G B
Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231-1000, USA.
Blood. 2001 Mar 1;97(5):1196-201. doi: 10.1182/blood.v97.5.1196.
Allogeneic stem cell transplantation (SCT) is now a commonplace procedure. Clinicians who care for patients with hematologic malignancies and aplastic anemia are almost certain to follow up patients after SCT. This review is intended to help clinicians observe patients for probably the most important late complication of SCT, chronic graft-versus-host disease (GVHD). It reviews the pathophysiology, risk factors, clinical manifestations, evaluation, treatment, and supportive care of chronic GVHD.
异基因干细胞移植（SCT）如今已是一种常见的治疗手段。诊治血液系统恶性肿瘤和再生障碍性贫血患者的临床医生几乎肯定会在干细胞移植后对患者进行随访。本综述旨在帮助临床医生观察干细胞移植可能最为重要的晚期并发症——慢性移植物抗宿主病（GVHD）。文中回顾了慢性移植物抗宿主病的病理生理学、危险因素、临床表现、评估、治疗及支持治疗。
