Meakin J R, Redpath T W, Hukins D W
Department of Bio-Medical Physics and Bio-Engineering, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK.
Clin Biomech (Bristol). 2001 Feb;16(2):121-8. doi: 10.1016/s0268-0033(00)00075-9.
To determine how partial removal of the nucleus changes the response of the annulus to compression.
The deformation of the annulus in the mid-sagittal plane, during compression, was determined from digital video images.
Several studies have shown that removal of the nucleus changes the external behaviour of the intervertebral disc, but few studies have investigated changes to internal behaviour.
Six frozen human lumbar discs were bisected in the sagittal plane to produce 12 specimens. The cut surfaces were marked with seven dots of Alcian blue stain. The specimens were sealed, enabling their internal structure to be viewed directly by a digital video recording system, and thawed. The video system recorded the response of each specimen as it was compressed by up to 1.8 mm at a rate of 0.2 mm s(-1). The displacements of the Alcian blue marks were measured using an image analysis program. Magnetic resonance imaging was used to investigate the validity of this technique.
Partial removal of the nucleus changed the way that the disc deformed under compression. A highly significant change in direction of movement was seen in the inner posterior region of the annulus.
Partial removal of the nucleus changes the response of the annulus to compression.
Partial denucleation of the human intervertebral disc is shown to change the direction of bulging of the inner annulus when the disc is compressed. Increases in shear stress, arising from these changes, may lead to further disc degeneration in the form of circumferential tears.
确定部分髓核摘除如何改变椎间盘纤维环对压缩的反应。
通过数字视频图像确定压缩过程中椎间盘在矢状面中部的变形情况。
多项研究表明，髓核摘除会改变椎间盘的外部行为，但很少有研究探讨其内部行为的变化。
将六个冷冻的人腰椎间盘在矢状面进行二等分，制成12个标本。在切割面上用阿尔辛蓝染料标记七个点。将标本密封，以便通过数字视频记录系统直接观察其内部结构，然后解冻。视频系统记录每个标本以0.2毫米/秒的速度被压缩至1.8毫米时的反应。使用图像分析程序测量阿尔辛蓝标记的位移。采用磁共振成像来研究该技术的有效性。
部分髓核摘除改变了椎间盘在压缩时的变形方式。在纤维环的内后部区域观察到运动方向发生了高度显著的变化。
部分髓核摘除改变了纤维环对压缩的反应。
研究表明，人类椎间盘部分髓核摘除会改变椎间盘压缩时纤维环内层膨出的方向。这些变化引起的剪切应力增加可能导致以环形撕裂形式出现的进一步椎间盘退变。
