Arrazaghi A A, Butany J W, Williams W G, Wigle D E, Rakowski H
Department of Cardiology, Toronto General Hospital and University of Toronto, Toronto, Ontario, Canada.
Can J Cardiol. 2001 Feb;17(2):197-202.
Hypertrophic cardiomyopathy - a genetically transmitted cardiac disorder - has diverse clinical, pathological and molecular manifestations. Echocardiography is the most reliable tool for clinical diagnosis of hypertrophic cardiomyopathy. Reduction of the intraventricular pressure gradient and improvement of symptoms are major objectives of all therapeutic strategies. The recently introduced concept of catheter-based interventional treatment involves selective coronary perforator branch injection of 96% ethanol to reduce septal thickness, left ventricular outflow obstruction, left ventricular filling pressure and symptoms. The long term morphological features after medical ablation are presented for the first time and compared with both the echocardiographic findings and the findings reported in the English-language literature. The findings show that injection of ethanol into the perforator branch is associated with a fairly localized area of myocardial scarring.
肥厚型心肌病——一种遗传性心脏疾病——具有多样的临床、病理和分子表现。超声心动图是肥厚型心肌病临床诊断最可靠的工具。降低心室内压力梯度和改善症状是所有治疗策略的主要目标。最近引入的基于导管的介入治疗概念包括选择性冠状动脉穿支分支注射96%乙醇以减少室间隔厚度、左心室流出道梗阻、左心室充盈压和症状。首次展示了药物消融后的长期形态学特征，并与超声心动图结果以及英文文献报道的结果进行了比较。结果表明，向穿支分支注射乙醇与相当局限的心肌瘢痕形成区域相关。
