Kurtkaya O, Elmaci I, Sav A, Pamir M N
Department of Neuropathology, Marmara University Institute of Neurological Sciences, Istanbul, Turkey.
Spinal Cord. 2001 Jan;39(1):57-60. doi: 10.1038/sj.sc.3101104.
We present the clinical, radiological, and pathological features of a solitary fibrous tumor in the spinal cord. This case is the seventh spinal solitary fibrous tumor in the literature. The tumor caused clinical symptoms in a 70-year-old female, which indicated compression of the spinal cord. Magnetic resonance imaging showed an intradural extramedullary mass at T3 vertebral level. Surgically, the tumor was firm, in an intradural extramedullary location and attached to the dura. Histologically, the tumor was composed of spindle cells in a collagen-rich matrix but exhibited regional variations. CD34 and vimentin were diffusely positive during immunohistochemical stain testing. The tumor displayed no positive staining for epithelial membrane antigen, cytokeratin, S-100 protein, smooth muscle actin or desmin. The Ki-67 labeling index was low. Solitary fibrous tumors have been found in a variety of locations suggesting that a solitary fibrous tumor has a mesenchymal origin. This rare tumor should be considered in the differential diagnosis of spinal tumors.
我们展示了一例脊髓孤立性纤维瘤的临床、放射学及病理学特征。该病例是文献报道中的第七例脊髓孤立性纤维瘤。此肿瘤致使一名70岁女性出现临床症状，提示脊髓受压。磁共振成像显示在T3椎体水平有一硬脊膜内髓外肿块。手术中，肿瘤质地坚硬，位于硬脊膜内髓外，与硬脑膜相连。组织学上，肿瘤由富含胶原基质的梭形细胞组成，但存在区域差异。免疫组织化学染色检测显示CD34和波形蛋白弥漫性阳性。肿瘤上皮膜抗原、细胞角蛋白、S - 100蛋白、平滑肌肌动蛋白或结蛋白均无阳性染色。Ki - 67标记指数较低。孤立性纤维瘤可见于多种部位，提示其起源于间叶组织。在脊髓肿瘤的鉴别诊断中应考虑到这种罕见肿瘤。
