Riley A.L., Kautz M.A., Geter B., Smurthwaite S.T., Pournaghash S., Melton P.M., Ferrari C.M.
Psychopharmacology Laboratory, Department of Psychology, The American University, Washington, D.C. 20016, USA.
Behav Pharmacol. 1991 Nov;2(4 And 5):323-334.
Although control of discriminative performance will often generalize to different doses of the training drug or to drugs from the same class as the training drug, the nature of this generalization is unknown. Prior work has suggested that the generalization is primarily quantal in nature with animals displaying either vehicle-appropriate or drug-appropriate responding, depending upon their detection of the drug stimulus. It has been questioned whether this quantal nature of generalization reflects a characteristic response to drug stimuli or whether such responding is a function of the specific training and testing procedures used to establish and measure drug discrimination learning. The present paper evaluated this issue by analyzing the generalization functions of individual subjects trained and tested within one specific drug discrimination procedure, i.e. the conditioned taste aversion design. Responding within this design was generally graded. It is clear that quantal responding is not a necessary outcome of drug generalization assessments and that the nature of generalization in drug discrimination learning is a function of the specific procedure utilized in training and testing the discrimination. The results of the present analysis are discussed in terms of other recent work reporting graded functions.
尽管对辨别性能的控制通常会推广到训练药物的不同剂量或与训练药物属于同一类别的药物，但这种推广的性质尚不清楚。先前的研究表明，这种推广主要是定量性质的，动物根据对药物刺激的检测表现出与溶剂匹配或与药物匹配的反应。有人质疑这种定量性质的推广是反映了对药物刺激的特征性反应，还是这种反应是用于建立和测量药物辨别学习的特定训练和测试程序的函数。本文通过分析在一种特定的药物辨别程序（即条件性味觉厌恶设计）中接受训练和测试的个体受试者的推广函数来评估这个问题。在这个设计中的反应通常是分级的。很明显，定量反应不是药物推广评估的必然结果，并且药物辨别学习中的推广性质是训练和测试辨别所使用的特定程序的函数。本文的分析结果将根据其他近期报告分级函数的研究进行讨论。
