Witkin J.M., Goldberg S.R.
Preclinical Pharmacology Branch, Addiction Research Center, National Institute on Drug Abuse, Baltimore, Maryland, USA.
Behav Pharmacol. 1992 Oct;3(5):455-463.
Behavioral effects of d-amphetamine, the cocaine analog, WIN 35,428, morphine, and pentobarbital were compared in NBR/NIH and F344CR1BR rats. Either nose-poke or lever-press responding was maintained under 3-min fixed-interval schedules of food presentation. The effects of morphine, WIN 35,428 and pentobarbital depended upon the rat strain studied: morphine increased nose-poke responding in NBR but not F344 rats; significant strain x dose interactions were observed with WIN 35,428; and pentobarbital was more potent in decreasing nose-poke responding in NBR than in F344 rats. No strain differences were observed in the behavioral effects of d-amphetamine. There were also prominent differences in the effects of drugs that were related to the nature of the response requirement. In both rat strains, nose-poke responding was affected differently than lever-press responding by morphine, d-amphetamine, and WIN 35,428. Pentobarbital produced effects that were independent of the specified response topography. A global underlying difference in these rat strains cannot be identified at present to account for the diversity of findings. The behavioral effects of these drugs appear to be influenced by a host of interactive factors including the drug, strain of animal, the baseline response rate and physical dimensions of the response.
在NBR/NIH和F344CR1BR大鼠中比较了右旋苯丙胺、可卡因类似物WIN 35,428、吗啡和戊巴比妥的行为效应。在3分钟的食物呈现固定间隔时间表下维持鼻触或杠杆按压反应。吗啡、WIN 35,428和戊巴比妥的效应取决于所研究的大鼠品系：吗啡增加了NBR大鼠的鼻触反应，但对F344大鼠没有影响；观察到WIN 35,428存在显著的品系×剂量相互作用；戊巴比妥在降低NBR大鼠的鼻触反应方面比F344大鼠更有效。在右旋苯丙胺的行为效应方面未观察到品系差异。与反应要求的性质相关的药物效应也存在显著差异。在两种大鼠品系中，吗啡、右旋苯丙胺和WIN 35,428对鼻触反应和杠杆按压反应的影响不同。戊巴比妥产生的效应与特定的反应形式无关。目前无法确定这些大鼠品系中存在一个全局的潜在差异来解释研究结果的多样性。这些药物的行为效应似乎受到许多相互作用因素的影响，包括药物、动物品系、基线反应率和反应的物理维度。
