Leander J D
J Pharmacol Exp Ther. 1981 Sep;218(3):728-33.
The effects of d-amphetamine, pentobarbital, morphine, chlorpromazine and triflupromazine were determined on key pecking by pigeons maintained under multiple and alternating-mixed fixed-ratio 30, fixed-interval 5-min schedules of grain presentation. Similar schedule performances were maintained under both the multiple and alternating mixed schedules. The effects of d-amphetamine and pentobarbital were similar under the multiple and alternating mixed schedules. Low doses of d-amphetamine and pentobarbital increased relatively low rates of responding in the fixed-interval component and higher doses decreased rates of responding in both the fixed-interval and fixed-ratio components. The effects of morphine, chlorpromazine and triflupromazine on fixed-interval rates of responding did not differ between the multiple and alternating mixed schedules. However, morphine, chlorpromazine and triflupromazine decreased responding under the alternating mixed fixed-ratio without affecting responding under the multiple fixed-ratio component. This selective decrease in fixed-ratio responding under the alternating mixed schedule by morphine, chlorpromazine and triflupromazine appears to be functionally similar to the effects of these drugs to decrease avoidance responding without affecting escape responding.
研究了右旋苯丙胺、戊巴比妥、吗啡、氯丙嗪和三氟拉嗪对在多重和交替混合固定比率30、固定间隔5分钟谷物呈现时间表下饲养的鸽子啄键行为的影响。在多重和交替混合时间表下，维持了相似的时间表表现。在多重和交替混合时间表下，右旋苯丙胺和戊巴比妥的作用相似。低剂量的右旋苯丙胺和戊巴比妥增加了固定间隔成分中相对较低的反应率，而高剂量则降低了固定间隔和固定比率成分中的反应率。吗啡、氯丙嗪和三氟拉嗪对固定间隔反应率的影响在多重和交替混合时间表之间没有差异。然而，吗啡、氯丙嗪和三氟拉嗪在交替混合固定比率下减少了反应，而不影响多重固定比率成分下的反应。吗啡、氯丙嗪和三氟拉嗪在交替混合时间表下对固定比率反应的这种选择性降低，在功能上似乎类似于这些药物减少回避反应而不影响逃避反应的效果。
