Maurice T., Bayle J., Privat A.
INSERM U. 336, Ecole Nationale Supérieure de Chimie, 8, rue de l'Ecole Normale F-34053 Montpellier Cedex 1, France.
Behav Pharmacol. 1995 Mar;6(2):167-175.
The effects of acute systemic administration of the Ca(2+) channel antagonist nimodipine were examined on learning capacities of adult Swiss mice. Tests included spontaneous alternation behaviour, for spatial working memory; and step-down passive avoidance and place learning in a water maze, for long-term memory. Nimodipine markedly impaired spontaneous alternation at doses of 0.3-1mg/kg i.p., and passive avoidance at doses of 0.3-3mg/kg i.p., as compared to the vehicle-treated animals. At 0.3mg/kg i.p., the drug did not alter motility in an open field, but significantly decreased performances in training trials and retention in the water maze. Subchronic nimodipine 0.3 and 1mg/kg once a day i.p. for 10 days) did not affect performances in the Y-maze and passive avoidance tests. These results show that acute nimodipine administration alters learning in adult mice, and argue for an involvement of voltage-dependent Ca(2+) channels in learning.
研究了急性全身给予钙通道拮抗剂尼莫地平对成年瑞士小鼠学习能力的影响。测试包括用于空间工作记忆的自发交替行为；以及用于长期记忆的避暗被动回避和水迷宫中的位置学习。与给予赋形剂处理的动物相比，尼莫地平腹腔注射剂量为0.3 - 1mg/kg时显著损害自发交替行为，剂量为0.3 - 3mg/kg时损害被动回避行为。腹腔注射0.3mg/kg时，该药物不改变旷场中的活动能力，但显著降低训练试验中的表现和水迷宫中的记忆保持。亚慢性给予尼莫地平0.3和1mg/kg（每天腹腔注射一次，共10天）不影响Y迷宫和被动回避测试中的表现。这些结果表明，急性给予尼莫地平会改变成年小鼠的学习能力，并提示电压依赖性钙通道参与学习过程。
