Margaglione M, Bossone A, Cappucci G, Colaizzo D, Grandone E, Di Minno G
Unità di Aterosclerosi e Trombosi, IRCCS Casa Sollievo della Sofferenza, viale Cappuccini, San Giovanni Rotondo, 71013 Foggia, Italy.
Haematologica. 2001 Feb;86(2):199-204.
C-reactive protein (C-RP) levels correlate with fibrinogen values and are predictive of coronary artery disease. Interleukin-6 (IL-6) strongly regulates the production of C-RP. A polymorphism (C/G-174) within the IL-6 gene has been shown to affect IL-6 gene expression and plasma concentrations.
In 598 asymptomatic employees of a hospital in Southern Italy, we investigated the association between IL-6 C/G-174 gene variants and plasma fibrinogen levels.
Subjects with IL-6 plasma levels >2.0 pg/mL had a higher body mass index (BMI) (24.5+/-1.2) than subjects with IL-6 levels below this cut-off value (23.7+/-1.2; p =0.005). No association was found with sex, cigarette smoking, or alcohol consumption (p always>0.05). When the whole sample was analyzed according to the IL-6 C/G-174 polymorphism, there was no difference with respect to age, sex, alcohol consumption, cigarette smoking, total cholesterol, triglycerides, and body mass index. Median plasma fibrinogen levels, as well as carriers of plasma levels of IL-6 >2.0 pg/mL and C-RP >0.33 mg/L, were similar among subjects with different IL-6 genotypes. Similarly, no difference was observed when only carriers of plasma levels of IL-6 >2.0 pg/mL were analyzed, whereas in those with C-RP >0.33 mg/L IL-6 GG carriers had significantly lower plasma fibrinogen levels.
The investigation of the IL-6 C/G-174 polymorphism does not seem to be a useful tool for predicting raised plasma fibrinogen levels.
C反应蛋白（C-RP）水平与纤维蛋白原值相关，可预测冠状动脉疾病。白细胞介素-6（IL-6）强烈调节C-RP的产生。IL-6基因内的一个多态性（C/G-174）已被证明会影响IL-6基因表达和血浆浓度。
在意大利南部一家医院的598名无症状员工中，我们研究了IL-6 C/G-174基因变异与血浆纤维蛋白原水平之间的关联。
IL-6血浆水平>2.0 pg/mL的受试者的体重指数（BMI）（24.5±1.2）高于IL-6水平低于此临界值的受试者（23.7±1.2；p =0.005）。未发现与性别、吸烟或饮酒有关联（p始终>0.05）。根据IL-6 C/G-174多态性对整个样本进行分析时，在年龄、性别、饮酒、吸烟、总胆固醇、甘油三酯和体重指数方面没有差异。不同IL-6基因型的受试者之间，血浆纤维蛋白原水平中位数，以及血浆IL-6>2.0 pg/mL和C-RP>0.33 mg/L的携带者的血浆纤维蛋白原水平相似。同样，仅分析血浆IL-6>2.0 pg/mL的携带者时未观察到差异，而在C-RP>0.33 mg/L的受试者中，IL-6 GG携带者的血浆纤维蛋白原水平显著较低。
对IL-6 C/G-174多态性的研究似乎不是预测血浆纤维蛋白原水平升高的有用工具。
