Margaglione M, Cappucci G, Colaizzo D, Pirro L, Vecchione G, Grandone E, Di Minno G
Unitá di Trombosi e Aterosclerosi, I.R.C.C.S. Casa Sollievo della Sofferenza, S. Giovanni Rotondo, Italy.
Thromb Haemost. 1998 Nov;80(5):805-10.
Elevated fibrinogen levels are an independent risk factor for cardiovascular ischemic disease. We investigated the relationship between cardiovascular ischemic risk factors, the fibrinogen Bbeta-chain G/A(-455) polymorphism and plasma fibrinogen levels in 989 apparently healthy subjects. Fibrinogen values were higher in subjects with C reactive protein (C-RP) >0.33 mg/dl, BMI >23.9 kg/m2, total cholesterol >4.84 mmol/l, triglycerides > 1.02 mmol/l, PAI-1 antigen >12.2 ng/ml, carriers of the A allele, first-degree relative history of coronary artery disease, or consuming >10 cigarettes per day (p<0.01). Men and ethanol drinkers showed lower plasma fibrinogen levels (p<0.01). The multivariate analysis confirmed the independent effect of C-RP, age, BMI, total cholesterol, gender, PAI-1, -455 G/A polymorphism, (p<0.05). BMI, total cholesterol, PAI-1, alcohol and smoking habit raised with the increase of age and differed between sexes. The A(-455) allele increasing effect was significant in women, especially in subjects aged <30 years, and in men aged <43 years. These results indicate that environmental factors contributed to a larger extent to fibrinogen variability, whereas the A(-455) allele was associated with a steeper increase in younger age quartiles.
纤维蛋白原水平升高是心血管缺血性疾病的独立危险因素。我们在989名看似健康的受试者中研究了心血管缺血危险因素、纤维蛋白原Bβ链G/A(-455)多态性与血浆纤维蛋白原水平之间的关系。纤维蛋白原值在C反应蛋白（C-RP）>0.33mg/dl、BMI>23.9kg/m²、总胆固醇>4.84mmol/l、甘油三酯>1.02mmol/l、PAI-1抗原>12.2ng/ml、A等位基因携带者、有冠状动脉疾病一级亲属史或每天吸烟>10支的受试者中更高（p<0.01）。男性和饮酒者的血浆纤维蛋白原水平较低（p<0.01）。多变量分析证实了C-RP、年龄、BMI、总胆固醇、性别、PAI-1、-455G/A多态性的独立作用（p<0.05）。BMI、总胆固醇、PAI-1、饮酒和吸烟习惯随年龄增长而升高，且存在性别差异。A(-455)等位基因的增加效应在女性中显著，尤其是在年龄<30岁的受试者以及年龄<43岁的男性中。这些结果表明，环境因素在更大程度上导致了纤维蛋白原的变异性，而A(-455)等位基因与较年轻年龄四分位数中纤维蛋白原水平的急剧升高有关。
