Cooper D K, Keogh A M
Transplantation Biology Research Center, Massachusetts General Hospital/Harvard Medical School, MGH East, Building 149-9019, 13th Street, Boston, MA 02129, USA.
Curr Opin Cardiol. 2001 Mar;16(2):105-9. doi: 10.1097/00001573-200103000-00005.
There is an increasing shortage of human donor hearts for transplantation. One potential solution is using hearts from a suitable animal source, such as the pig. A committee of the International Society for Heart and Lung Transplantation has reviewed the current status of research into xenotransplantation. Furthermore, the committee considered what results in the pig-to-nonhuman primate experimental model would justify a clinical trial of xenotransplantation, and the criteria for selecting patients to be entered in the trial. This review emphasizes initial patient selection issues, although the committee's overall conclusions and recommendations are summarized. Although the current experimental results do not presently justify initiating a clinical trial, the committee concluded that xenotransplantation theoretically has immense potential, and that research in this field should be encouraged and supported. Human cadaveric organ donation will still be of the highest priority for the foreseeable future.
用于移植的人类供体心脏的短缺日益严重。一个潜在的解决方案是使用来自合适动物源的心脏，比如猪。国际心肺移植学会的一个委员会审查了异种移植的研究现状。此外，该委员会还考虑了猪到非人灵长类动物实验模型的哪些结果将证明异种移植临床试验的合理性，以及选择纳入试验患者的标准。本综述强调了最初的患者选择问题，同时也总结了委员会的总体结论和建议。虽然目前的实验结果目前尚不能证明启动临床试验的合理性，但委员会得出结论，异种移植在理论上具有巨大潜力，应该鼓励和支持该领域的研究。在可预见的未来，人类尸体器官捐赠仍将是最优先考虑的。
