Chitnis C E
Malaria Research Group, International Center for Genetic Engineering and Biotechnology (ICGEB), Aruna Asaf Ali Marg, New Delhi, India.
Curr Opin Hematol. 2001 Mar;8(2):85-91. doi: 10.1097/00062752-200103000-00005.
The invasion of erythrocytes by malaria parasites is a multi-step process that requires a series of highly specific molecular interactions. Here, the authors review what has been learned about receptor-ligand interactions that mediate erythrocyte invasion. Parasite proteins involved in these interactions are promising candidates for malaria vaccines. Clear understanding of these interactions is important for the rational design of vaccines that attempt to inhibit invasion and prevent malaria.
疟原虫对红细胞的入侵是一个多步骤过程，需要一系列高度特异性的分子相互作用。在此，作者回顾了关于介导红细胞入侵的受体-配体相互作用的已有认识。参与这些相互作用的寄生虫蛋白是疟疾疫苗的有前景的候选物。清楚了解这些相互作用对于合理设计试图抑制入侵和预防疟疾的疫苗很重要。
