疟原虫诱导的红细胞空泡筏
Erythrocytic vacuolar rafts induced by malaria parasites.
作者信息
Haldar K, Samuel B U, Mohandas N, Harrison T, Hiller N L
机构信息
Departments of Pathology and Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA.
出版信息
Curr Opin Hematol. 2001 Mar;8(2):92-7. doi: 10.1097/00062752-200103000-00006.
Studies in the past year displaced long-standing dogmas and provided many new molecular insights into how proteins and solutes move between the erythrocyte plasma membrane and the malarial vacuole. Highlights include a demonstration that (1) detergent-resistant membrane (DRM) rafts exist in the red cell membrane and their resident proteins are detected as rafts in the plasmodial vacuole, (2) a voltage-gated channel in the infected red cell membrane mediates uptake of extracellular nutrient solutes, and (3) intraerythrocytic membranes transport a parasite-encoded adherence antigen to the red cell surface.
过去一年的研究推翻了长期以来的教条，并提供了许多关于蛋白质和溶质如何在红细胞质膜与疟原虫液泡之间移动的新分子见解。重点包括证明：（1）红细胞膜中存在抗去污剂膜（DRM）筏，并且它们的驻留蛋白在疟原虫液泡中被检测为筏；（2）感染红细胞膜中的电压门控通道介导细胞外营养溶质的摄取；（3）红细胞内的膜将一种寄生虫编码的黏附抗原转运到红细胞表面。
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