Haldar K, Samuel B U, Mohandas N, Harrison T, Hiller N L
Department of Pathology, Northwestern University, 303 East Chicago Avenue, Chicago, IL 60611, USA.
Int J Parasitol. 2001 Oct;31(12):1393-401. doi: 10.1016/s0020-7519(01)00251-x.
The mature human erythrocyte is a simple cell that is devoid of intracellular organelles and does not show endocytic or phagocytic activity at the plasma membrane. However, following infection by Plasmodium, the erythrocyte undergoes several morphological and functional changes. Parasite-derived proteins are exported into the erythrocyte cytoplasm and to the membrane, while several proteins are localised to the parasitophorous vacuolar membrane and to the tubovesicular membranous network structures surrounding the parasite. Recent evidence indicates that multiple host proteins, independent of the type of their membrane anchor, that exist in detergent-resistant membrane (DRM) rafts or microdomains enter this apicomplexan vacuole. The internalised host components along with the parasite-encoded transmembrane protein PfEXP1 can be detected as DRM rafts in the vacuole. It appears that in Plasmodium-infected erythrocytes lipid rafts may play a role in endovacuolation and macromolecular transport.
成熟的人类红细胞是一种简单的细胞，没有细胞内细胞器，并且在质膜上不表现出内吞或吞噬活性。然而，在被疟原虫感染后，红细胞会经历多种形态和功能变化。寄生虫衍生的蛋白质被输出到红细胞细胞质和膜上，而几种蛋白质则定位于寄生泡膜和围绕寄生虫的管状囊泡膜网络结构。最近的证据表明，存在于抗去污剂膜（DRM）筏或微结构域中的多种宿主蛋白，无论其膜锚定类型如何，都会进入这种顶复门寄生虫的液泡。内化的宿主成分与寄生虫编码的跨膜蛋白PfEXP1一起可以在液泡中检测为DRM筏。似乎在疟原虫感染的红细胞中，脂筏可能在内泡形成和大分子运输中起作用。
