Kaplan J, Pollak M R
Renal Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Curr Opin Nephrol Hypertens. 2001 Mar;10(2):183-7. doi: 10.1097/00041552-200103000-00005.
There is increasing recognition of the importance of genetic factors in the development of focal segmental glomerulosclerosis and related proteinuric disorders. Recently, four genes have been identified which, when defective, cause focal segmental glomerulosclerosis or nephrosis. All of these genes appear to be important in the maintenance of glomerular podocyte function. However, not all cases of familial nephrosis or proteinuria are explained by defects in these genes.
遗传因素在局灶节段性肾小球硬化及相关蛋白尿性疾病发生发展中的重要性日益受到认可。最近，已鉴定出四个基因，这些基因发生缺陷时会导致局灶节段性肾小球硬化或肾病。所有这些基因似乎在维持肾小球足细胞功能方面都很重要。然而，并非所有家族性肾病或蛋白尿病例都可由这些基因的缺陷来解释。
