Tsunoda K, Baer T, Niimi S
Department of Otolaryngology, Nissan Tamagawa Hospital, 4-8-1 Seta, Setagaya-ku, Tokyo, 158, Japan.
Laryngoscope. 2001 Mar;111(3):453-7. doi: 10.1097/00005537-200103000-00014.
To study the long-term results of autologous transplantation of fascia into the vocal fold, and to evaluate our use of autologous transplantation instead of bovine collagen injection in cases of glottal incompetence.
Retrospective study of the patients who have undergone autologous fascia transplantation using our new technique.
Follow-up studies were performed for at least 1 year (up to 3 y) on 9 autologous fascia transplant patients (6 cases with type 1 procedures and 3 cases with type 2 procedures). Clinical observations, including laryngeal stroboscopy, and measurement of maximum phonation time (MPT) were carried out.
During 3 months after autologous fascia transplantation, MPT gradually increased and stroboscopy showed improved glottal closure. These improvements continued beyond 1 year in all cases of type 1 surgery and 2 of 3 cases of type 2 surgery.
Autologous transplantation of fascia into the vocal folds as a phonosurgical treatment for glottal incompetence yields excellent long-term results. Temporal fascia appears to be a highly suitable tissue for transplantation in Reinke's space. However, the fascia is less suitable for transplantation in the muscle. We speculate that transplantation of temporal fascia leads to regeneration of vocal fold tissue, perhaps using a mechanism similar to stem cell transplantation in other organs.
研究自体筋膜移植至声带的长期效果，并评估在声门闭合不全病例中使用自体移植而非注射牛胶原蛋白的情况。
对采用我们新技术进行自体筋膜移植的患者进行回顾性研究。
对9例自体筋膜移植患者（6例采用1型手术，3例采用2型手术）进行了至少1年（最长3年）的随访研究。进行了包括喉动态镜检查在内的临床观察以及最大发声时间（MPT）测量。
自体筋膜移植后3个月内，MPT逐渐增加，动态镜检查显示声门闭合改善。在所有1型手术病例以及3例2型手术中的2例中，这些改善持续超过1年。
自体筋膜移植至声带作为声门闭合不全的发声外科治疗方法可产生优异的长期效果。颞筋膜似乎是在任克间隙进行移植的高度合适的组织。然而，该筋膜不太适合在肌肉中移植。我们推测颞筋膜移植可导致声带组织再生，可能是通过类似于其他器官中干细胞移植的机制。
