Otorhinolaryngology and Head & Neck Surgery Department, UNIFESP- EPM.
Braz J Otorhinolaryngol. 2011 Mar-Apr;77(2):185-90. doi: 10.1590/s1808-86942011000200008.
The ideal approach for the treatment of glottal insufficiency remains a challenge for laryngologists.
This experimental study assessed the histological changes and fibrosis caused by autologous fascia lata grafts into the rabbit voice muscle.
A clinical and experimental study.
A 0.2 × 0.2 cm fragment of autologous fascia lata was grafted into the right voice muscle of 14 adult rabbits. Animals were euthanized 30 or 60 days post-procedure and histology of the excised vocal folds was carried out.
No extensive edema, necrosis or foreign body-type reaction was observed at any time. No significant inflammatory reaction or fibrosis was seen at 30 or 60 days.
The presence of fascia lata in the rabbit voice muscle had no significant influence on inflammation, and does not increase fibrosis. Rabbit voice muscle shows good tolerance to fascia lata grafting.
本实验研究评估了自体阔筋膜移植物植入兔喉肌引起的组织学变化和纤维化。
将 0.2×0.2cm 大小的自体阔筋膜碎片移植到 14 只成年兔的右侧喉肌中。术后 30 或 60 天处死动物，切除声带进行组织学检查。
任何时间均未见广泛水肿、坏死或异物反应。30 或 60 天未见明显炎症反应或纤维化。
阔筋膜在兔喉肌中的存在对炎症没有明显影响，也不会增加纤维化。兔喉肌对阔筋膜移植具有良好的耐受性。
