Cornish K M, Munir F, Cross G
Section of Developmental Psychiatry, Division of Psychiatry, Queens Medical Centre, University of Nottingham, UK.
J Cogn Neurosci. 2001 Jan 1;13(1):144-50. doi: 10.1162/089892901564126.
Memory and attention processing were examined in a group of 15 adult Fragile-X syndrome (FXS) males with Fragile-X mental retardation 1 (FMR-1) full mutation and compared to two control groups: a learning disabled (LD) control and a normal functioning control. Performance was assessed across a wide range of tasks including working memory, recognition memory, selective attention, sustained attention, and attentional switching. All three groups performed at a comparable level on recognition memory tasks, and the Fragile-X males and LD control group performed worse than the control group on tasks of working memory and sustained attention. On a task of executive function, the Fragile-X males demonstrated a significant deficit in comparison to the LD control group and the normal control group, but performed better than the LD control group and at a comparable level to the control group on tasks of selective attention. Molecular analyses of the lymphocyte DNA provided little evidence for a correlation between expansion size and performance on tasks of memory and attention. The findings from the present study are discussed in the context of functional neuroimaging and brain-behavior-molecular correlates.
对一组15名患有脆性X智力低下1（FMR-1）全突变的成年脆性X综合征（FXS）男性进行了记忆和注意力处理方面的检查，并与两个对照组进行了比较：一个学习障碍（LD）对照组和一个正常功能对照组。通过广泛的任务评估了他们的表现，包括工作记忆、识别记忆、选择性注意力、持续性注意力和注意力转换。在识别记忆任务上，所有三组的表现相当，而脆性X男性和LD对照组在工作记忆和持续性注意力任务上的表现比对照组差。在执行功能任务上，与LD对照组和正常对照组相比，脆性X男性表现出显著缺陷，但在选择性注意力任务上比LD对照组表现更好，与对照组表现相当。淋巴细胞DNA的分子分析几乎没有提供证据表明扩增大小与记忆和注意力任务表现之间存在相关性。本研究结果在功能性神经影像学以及脑-行为-分子相关性的背景下进行了讨论。
