Holcomb B W, Thigpen J T, Puckett J F, Morrison F S
Cancer. 1975 May;35(5):1459-64. doi: 10.1002/1097-0142(197505)35:5<1459::aid-cncr2820350534>3.0.co;2-9.
A case of generalized melanosis complicating disseminated malignant melanoma in pregnancy is described. Four features of this case, unique in combination, are discussed. First, generalized melanosis is a rare complication in macrophages of skin and other areas. Secondly, extensive bone lesions in the absence of roentgenographic changes are an uncommon occurrence. Thirdly, pregnancy probably has little effect on the course of melanoma, as illustrated by this case and a review of the literature. Finally, placental metastases may be more common than generally thought, yet may have little significance to the fetus.
本文描述了一例妊娠期播散性恶性黑色素瘤合并全身黑色素沉着症的病例。讨论了该病例四个独特组合的特征。首先，全身黑色素沉着症是皮肤和其他部位巨噬细胞罕见的并发症。其次，在无X线改变的情况下出现广泛的骨病变并不常见。第三，如本病例及文献综述所示，妊娠可能对黑色素瘤的病程影响不大。最后，胎盘转移可能比一般认为的更常见，但对胎儿可能意义不大。
