Bork K, Korting G W, Rumpelt H J
Hautarzt. 1977 Sep;28(9):463-8.
A patient with widely metastasized malignant melanoma assocaited with diffuse melanosis is presented. The widespread metastases in liver; skin and tonsilla are remarkable. The cutaneous melanosis in the form of the slate-blue colour caused by the increased dermal melanin deposits can arise in two different ways. One possibility is that melanin or precursors can be released from liver or other metastases and reach the dermis via the circulation. On the other hand a diffuse direct haematogenic single cell metastatic formation in the dermis with melanin formation and release can occur. In the case of the described patient the first etiopathology is dominating as it is shown by the light and electron microscopical results presented here.
本文报告一例广泛转移的恶性黑色素瘤伴弥漫性黑变病患者。肝脏、皮肤和扁桃体广泛转移显著。真皮黑色素沉积增加导致的蓝灰色皮肤黑变病可通过两种不同方式出现。一种可能性是黑色素或其前体可从肝脏或其他转移灶释放，经循环到达真皮。另一方面，真皮内可发生弥漫性直接血源性单细胞转移形成，并伴有黑色素形成和释放。在所描述的患者中，如本文所示的光镜和电镜结果表明，第一种病因学占主导地位。
