Lindemans F W, Heethaar R M, van der Gon J J, Zimmerman A N
Cardiovasc Res. 1975 Jan;9(1):95-104. doi: 10.1093/cvr/9.1.95.
End-diastolic current thresholds have been measured in 13 open chested dogs as a function of electrode radius by stimulating the left ventricle with epicardial disc electrodes ranging in a radius from 0-3 mm to 9 mm. Thresholds for cathodal rectangular short stimuli as well as specifically for cathodal make stimulation, proved to be proportional to the electrode radius to the power 1-5. This relationship between radius and threshold can be explained theoretically, assuming that electrical stimulation results in a propagated depolarization front if a critical current density is reached somewhere in the myocardium. The current distribution measured over the electrode and the site of initial depolarization in the tissue are in accordance with this theoretical explanation.
通过使用半径范围从0 - 3毫米到9毫米的心外膜圆盘电极刺激左心室，在13只开胸犬中测量了舒张末期电流阈值与电极半径的函数关系。阴极矩形短刺激以及特别是阴极接通刺激的阈值，被证明与电极半径的1 - 5次方成正比。如果假设在心肌中的某处达到临界电流密度时电刺激会导致传播的去极化波前，那么半径与阈值之间的这种关系可以从理论上进行解释。在电极上测量的电流分布以及组织中初始去极化的部位与这种理论解释相符。
