新型单胺氧化酶-B抑制剂PF9601N的神经保护作用
Neuroprotective aspects of a novel MAO-B inhibitor PF9601N.
作者信息
Pérez V, Morón J, Pastó M, Unzeta M
机构信息
Departament de Bioquímica i de Biologia Molecular, Facultat de Medicina, Universitat Autònoma de Barcelona, 08193 Bellalterra, Spain.
出版信息
Neurobiology (Bp). 2000;8(3-4):231-6.
PF9601N is an acetylenic tryptamine derivative devoid of amphetamine-like properties, that behaves as suicide MAO-B inhibitor more potent than l-deprenyl. It is highly selective towards MAO-B and it neuroprotects from the neurotoxicity induced in C57Bl/6 adult mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). PF9601N also shows in vitro antioxidant properties by inhibiting the dopamine autoxidation. A potential therapeutic use in Parkinson's disease treatment is proposed for this compound.
PF9601N是一种不含苯丙胺样特性的炔丙基色胺衍生物，其作为自杀性单胺氧化酶B（MAO-B）抑制剂的作用比左旋司来吉兰更强。它对MAO-B具有高度选择性，并且能对1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的C57Bl/6成年小鼠神经毒性起到神经保护作用。PF9601N还通过抑制多巴胺自氧化表现出体外抗氧化特性。有人提出该化合物在帕金森病治疗中具有潜在的治疗用途。
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