Aouad M T, Siddik S S, Rizk L B, Zaytoun G M, Baraka A S
Department of Anesthesiology, American University of Beirut, Beirut, Lebanon.
Anesth Analg. 2001 Mar;92(3):636-40. doi: 10.1097/00000539-200103000-00015.
In this double-blinded, randomized, placebo-controlled study, we assessed the effect of dexamethasone 0.5 mg/kg IV administered preoperatively in 110 children 2-12 yr old, undergoing electrodissection adenotonsillectomy, using a standardized anesthetic technique. The incidence of early and late vomiting, the time to first oral intake, the quality of oral intake, the satisfaction scores, and the duration of IV hydration were compared in both groups. The overall incidence of vomiting, as well as the incidence of late vomiting, was significantly less in the Dexamethasone group as compared with the Saline group (23% and 19% vs 51% and 34%, respectively). The time to first oral intake and the duration of IV hydration were shorter in the Dexamethasone group compared with the Saline group (P < 0.05). The quality of oral intake and the satisfaction scores were better in the Dexamethasone group than in the Saline group (P < 0.05). This report confirms the beneficial effect of IV dexamethasone on both vomiting and oral intake in children undergoing electrodissection adenotonsillectomy.
In this double-blinded, placebo-controlled study, we examined the efficacy of a single dose of dexamethasone 0.5 mg/kg IV on posttonsillectomy vomiting and oral intake in children 2-12 yr old. Dexamethasone significantly decreased the incidence of postoperative vomiting during the first 24 h, shortened the time to the first oral intake and the duration of IV hydration, and improved the quality of oral intake and the satisfaction scores of the patients.
在这项双盲、随机、安慰剂对照研究中，我们评估了在110名2至12岁接受电切腺样体扁桃体切除术的儿童中，术前静脉注射0.5mg/kg地塞米松的效果，采用标准化麻醉技术。比较了两组的早期和晚期呕吐发生率、首次经口进食时间、经口进食质量、满意度评分以及静脉补液持续时间。与生理盐水组相比，地塞米松组的总体呕吐发生率以及晚期呕吐发生率显著更低（分别为23%和19% 对比 51%和34%）。与生理盐水组相比，地塞米松组的首次经口进食时间和静脉补液持续时间更短（P < 0.05）。地塞米松组的经口进食质量和满意度评分优于生理盐水组（P < 0.05）。本报告证实了静脉注射地塞米松对接受电切腺样体扁桃体切除术儿童的呕吐和经口进食均有有益作用。
在这项双盲、安慰剂对照研究中，我们研究了静脉注射单剂量0.5mg/kg地塞米松对2至12岁儿童扁桃体切除术后呕吐和经口进食的疗效。地塞米松显著降低了术后24小时内的呕吐发生率，缩短了首次经口进食时间和静脉补液持续时间，并改善了经口进食质量和患者的满意度评分。
