The disintegration of a molecule: the role of gelsolin in FAF, familial amyloidosis (Finnish type).
作者信息
Robinson R C, Choe S, Burtnick L D
出版信息
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2117-8. doi: 10.1073/pnas.051635098.
Abstract
摘要
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The disintegration of a molecule: the role of gelsolin in FAF, familial amyloidosis (Finnish type).分子的解体：凝溶胶蛋白在芬兰型家族性淀粉样变性（FAF）中的作用。
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2117-8. doi: 10.1073/pnas.051635098.
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Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type.无钙凝溶胶蛋白的不稳定可能与芬兰型家族性淀粉样变性中的蛋白水解无关。
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Non-Invasive Imaging of Amyloid Deposits in a Mouse Model of AGel Using Tc-Modified Nanobodies and SPECT/CT.使用锝修饰的纳米抗体和SPECT/CT对AGel小鼠模型中淀粉样沉积物进行无创成像。
Mol Imaging Biol. 2016 Dec;18(6):887-897. doi: 10.1007/s11307-016-0960-y.
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Chaperone nanobodies protect gelsolin against MT1-MMP degradation and alleviate amyloid burden in the gelsolin amyloidosis mouse model.伴侣纳米抗体可保护凝溶胶蛋白免受MT1-MMP降解，并减轻凝溶胶蛋白淀粉样变性小鼠模型中的淀粉样蛋白负担。
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The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic.血浆凝溶胶蛋白的8 kDa和5 kDa片段通过成核聚合机制形成淀粉样纤维，而68 kDa片段不具有淀粉样变性。
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本文引用的文献
1
Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type.无钙凝溶胶蛋白的不稳定可能与芬兰型家族性淀粉样变性中的蛋白水解无关。
Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2334-9. doi: 10.1073/pnas.041452598. Epub 2001 Feb 20.
2
Elucidating the mechanism of familial amyloidosis- Finnish type: NMR studies of human gelsolin domain 2.阐明芬兰型家族性淀粉样变性的机制：人凝溶胶蛋白结构域2的核磁共振研究
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):10706-11. doi: 10.1073/pnas.180310097.
3
Mapping the functional surface of domain 2 in the gelsolin superfamily.
Biochemistry. 2000 May 9;39(18):5322-31. doi: 10.1021/bi992364d.
4
Domain movement in gelsolin: a calcium-activated switch.凝溶胶蛋白中的结构域运动：一种钙激活开关。
Science. 1999 Dec 3;286(5446):1939-42. doi: 10.1126/science.286.5446.1939.
5
Equilibria and kinetics of folding of gelsolin domain 2 and mutants involved in familial amyloidosis-Finnish type.凝溶胶蛋白结构域2及与芬兰型家族性淀粉样变性相关的突变体的折叠平衡与动力学
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11247-52. doi: 10.1073/pnas.96.20.11247.
6
Determination of the gelsolin binding site on F-actin: implications for severing and capping.凝溶胶蛋白在F-肌动蛋白上结合位点的确定：对切割和封端的影响。
Biophys J. 1998 Feb;74(2 Pt 1):764-72. doi: 10.1016/S0006-3495(98)74001-9.
7
The crystal structure of plasma gelsolin: implications for actin severing, capping, and nucleation.血浆凝溶胶蛋白的晶体结构：对肌动蛋白切断、加帽和成核的影响。
Cell. 1997 Aug 22;90(4):661-70. doi: 10.1016/s0092-8674(00)80527-9.
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Spectroscopic studies of a phosphoinositide-binding peptide from gelsolin: behavior in solutions of mixed solvent and anionic micelles.凝溶胶蛋白中一种磷酸肌醇结合肽的光谱研究：在混合溶剂和阴离子胶束溶液中的行为
Biophys J. 1995 Dec;69(6):2695-702. doi: 10.1016/S0006-3495(95)80140-2.
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Structure of gelsolin segment 1-actin complex and the mechanism of filament severing.凝溶胶蛋白1片段-肌动蛋白复合物的结构及细丝切断机制。
Nature. 1993 Aug 19;364(6439):685-92. doi: 10.1038/364685a0.
10
Molecular model of an actin filament capped by a severing protein.由一种切割蛋白封端的肌动蛋白丝的分子模型。
J Struct Biol. 1995 Sep-Oct;115(2):144-50. doi: 10.1006/jsbi.1995.1038.
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