Hull M G, Braunsberg H, Irving D
Clin Chim Acta. 1975 Jan 6;58(1):71-6. doi: 10.1016/0009-8981(75)90486-6.
Urinary total oestrogen values in late pregnancy have been determined by an automated, fluorimetric method based on the Kober reaction and Ittrich extraction. The normal range was obtained from 360 samples from 56 patients. The mean value at 40 weeks gestation was 52.6 mg/24 h and the 95 per cent probability bounds were 29.1 and 95.3 mg/24 h, obtained after initial calculations on logarithm values. "Small for dates" foetuses in good condition at birth were associated with oestrogen values generally below the normal mean. They were usually well discriminated from foetuses that died in the uterus. These were always associated with oestrogen values below or approaching 10 mg/24 h before death except when growth had been normal and death was due to mechanical complications at delivery.
妊娠晚期尿中总雌激素值已通过基于科伯反应和伊特里希萃取法的自动化荧光法测定。正常范围取自56名患者的360份样本。妊娠40周时的平均值为52.6毫克/24小时，经对数初始计算后得到的95%概率界限为29.1和95.3毫克/24小时。出生时状况良好的“小于孕周”胎儿，其雌激素值通常低于正常平均值。它们通常能与死于子宫内的胎儿很好地区分开来。除了生长正常且死亡是由于分娩时的机械性并发症外，这些死于子宫内的胎儿在死亡前雌激素值总是低于或接近10毫克/24小时。
