Giorgi E P, Gore M B, Tye G M
Ann Clin Biochem. 1977 Nov;14(6):335-42. doi: 10.1177/000456327701400187.
Serum oestrogen concentration and urinary oestrogen excretion were measured in 134 women in the last trimester of pregnancy. An automated fluorimetric method was used for urinary oestrogens and a radioimmunoassay which measures both free and conjugated oestrogens, with the exception of sulphates, was employed for serum. Pregnancies were classified into a 'normal' or 'abnormal' group according to the clinical state of the baby at birth. The range of values for both serum and urinary oestrogens was wide at each stage of gestation and the mean values in the two groups were not significantly different. It was concluded that for a valid indication of fetal well-being serial determinations were essential, and that serum and urinary oestrogens were of comparable predictive value. Expressing the urinary results in terms of creatinine excretion did not improve their predictive value.
对134名处于妊娠晚期的女性测定了血清雌激素浓度和尿雌激素排泄量。采用自动荧光法测定尿雌激素，采用放射免疫分析法测定血清雌激素，该方法可同时测定游离雌激素和结合雌激素，但不包括硫酸盐结合雌激素。根据婴儿出生时的临床状况将妊娠分为“正常”或“异常”组。在妊娠的每个阶段，血清和尿雌激素的值范围都很宽，两组的平均值没有显著差异。得出的结论是，为了有效指示胎儿健康状况，连续测定至关重要，并且血清和尿雌激素具有相当的预测价值。以肌酐排泄量表示尿检测结果并不能提高其预测价值。
