Wang H H, Chou C J, Liao J F, Chen C F
Department and Institute of Pharmacology, National Yang-Ming University, No. 155, Sec. 2, Li-Nong Street, Pei-Tou Dist. (112), Taipei (11221), Taiwan.
Eur J Pharmacol. 2001 Feb 16;413(2-3):221-5. doi: 10.1016/s0014-2999(00)00913-4.
Dehydroevodiamine has been reported to have anticholinesterase activity and an anti-amnesic effect. This study examined the effects of dehydroevodiamine on scopolamine- and beta-amyloid peptide-(25--35)-induced amnesia in mice, using a step-through passive avoidance test. Similarly to the cholinesterase inhibitor, physostigmine (0.03--0.3 mg/kg, i.p.), dehydroevodiamine (0.75--12.0 mg/kg, i.p.) administered 30 min before the training trial, immediately after the training trial, and 30 min before the retention test significantly improved scopolamine- and beta-amyloid peptide-(25--35)-induced amnesia. In beta-amyloid peptide-(25--35)-induced amnesia, the rank order of anti-amnesic potency in these three administration schedules for dehydroevodiamine was different from that for physostigmine. Furthermore, dehydroevodiamine was more potent to improve beta-amyloid peptide-(25--35)-induced amnesia than scopolamine-induced amnesia when administered before the training trial. These results suggested that dehydroevodiamine may have an action other than that of an anticholinesterase and may be a novel and effective ligand for improvement of beta-amyloid type amnesia.
据报道，吴茱萸次碱具有抗胆碱酯酶活性和抗遗忘作用。本研究采用穿梭箱被动回避试验，考察了吴茱萸次碱对东莨菪碱和β-淀粉样肽（25-35）诱导的小鼠遗忘的影响。与胆碱酯酶抑制剂毒扁豆碱（0.03-0.3mg/kg，腹腔注射）类似，在训练试验前30分钟、训练试验后立即以及在记忆测试前30分钟腹腔注射吴茱萸次碱（0.75-12.0mg/kg）可显著改善东莨菪碱和β-淀粉样肽（25-35）诱导的遗忘。在β-淀粉样肽（25-35）诱导的遗忘中，吴茱萸次碱在这三种给药方案中的抗遗忘效力顺序与毒扁豆碱不同。此外，在训练试验前给药时，吴茱萸次碱改善β-淀粉样肽（25-35）诱导的遗忘比改善东莨菪碱诱导的遗忘更有效。这些结果表明，吴茱萸次碱可能具有除抗胆碱酯酶以外的作用，可能是一种改善β-淀粉样蛋白型遗忘的新型有效配体。
