Shan Qi-Yuan, Sang Xia-Nan, Hui Hui, Shou Qi-Yang, Fu Hui-Ying, Hao Min, Liu Kao-Hua, Zhang Qiao-Yan, Cao Gang, Qin Lu-Ping
College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, China.
Affiliated Secondary Hospital, Zhejiang Chinese Medical University, Hangzhou, China.
Front Pharmacol. 2020 Mar 6;11:133. doi: 10.3389/fphar.2020.00133. eCollection 2020.
Herbal medicine is a major part of traditional Chinese medicine (TCM), which is evolved as a system of medical practice from ancient China. The use of herbal medicine is mainly based on practice and theories and concepts rooted in ancient philosophy. In the era of evidence-based medicine, it is essential to accurately evaluate herbal remedy with standard/modern medical practice approaches. (A. Juss.) Hartley (TR), a medicinal plant with diversify bioactive components, has been broadly used to treat pain and gastrointestinal disorders in TCM. However, TR has also been reported to have potential toxicity by long-term use or excessive doses, though the associated compounds are yet to be identified. TR is usually processed, and/or combined with other herbs in TCM formulas in order to achieve a synergistic effect or reduce its toxicity. Since processing or polyherbal formulation of TR may lead to changes in its chemical composition and contents, quality, efficacy and toxicity, comparison of TR samples before and after processing, as well as its combination with other medicines, would provide useful knowledge of bioactive compounds, efficacy and toxicity of this valuable medicinal plant. Here we reviewed the recent studies about the phytochemistry, pharmacokinetic behaviors and toxicity of TR under various processing or polyherbal formulation conditions, which would expand our understanding of mechanisms of TR's efficacy and toxicity and be valuable for quality control in industrial manufacturing, future medicinal research, and safety and rational use of TR in TCM.
草药是中医的重要组成部分，中医是从古代中国发展而来的一种医学实践体系。草药的使用主要基于实践以及源于古代哲学的理论和概念。在循证医学时代，采用标准/现代医学实践方法准确评估草药疗法至关重要。（A. 贾斯）哈特利（TR）是一种具有多种生物活性成分的药用植物，在中医中广泛用于治疗疼痛和胃肠道疾病。然而，也有报道称，长期使用或过量服用TR可能具有潜在毒性，尽管相关化合物尚未确定。在中医配方中，TR通常会经过炮制，和/或与其他草药配伍，以达到协同作用或降低其毒性。由于TR的炮制或多草药配方可能会导致其化学成分、含量、质量、功效和毒性发生变化，比较TR炮制前后以及与其他药物配伍后的样本，将有助于了解这种珍贵药用植物的生物活性成分、功效和毒性。在此，我们综述了近期关于TR在各种炮制或多草药配方条件下的植物化学、药代动力学行为和毒性的研究，这将拓展我们对TR功效和毒性机制的理解，并对工业生产中的质量控制、未来的药物研究以及中医中TR的安全合理使用具有重要价值。
