Munster A M, Smith-Meek M, Shalom A
Baltimore Regional Burn Center, Johns Hopkins Bayview Medical Center and the Department of Surgery, Johns Hopkins University, 4940, Eastern Avenue, Baltimore, MD 21224, USA.
Burns. 2001 Mar;27(2):150-3. doi: 10.1016/s0305-4179(00)00096-6.
In a prospective, randomized study seventeen patients received skin grafts to a freshly excised burn wound. One group was grafted with a deantigenized dermal matrix and immediately overgrafted with thin autograft. The second group was grafted with dermal matrix, which was then covered with bank allograft for protection, and autografted 1 week later. Each group also received a standard split thickness control graft. Assessment was carried out for up to 1 year. There were no statistically significant differences of graft take between any of the groups, or in the Vancouver scar score at follow-up. Thin donor sites used for dermal matrix coverage healed faster than standard control graft sites, P<0.001. Immediate grafting of acellular dermal matrix with thin autograft works well and leads to an acceptable late result, with faster donor site healing than standard split thickness grafts.
在一项前瞻性随机研究中，17例患者接受了新鲜切除烧伤创面的皮肤移植。一组移植去抗原化真皮基质，随后立即覆盖薄的自体皮。第二组移植真皮基质，然后用库存同种异体皮覆盖以作保护，1周后进行自体皮移植。每组还接受了标准的中厚对照移植。评估持续了1年。各移植组之间的移植成活率或随访时的温哥华瘢痕评分均无统计学显著差异。用于覆盖真皮基质的薄供皮区比标准对照移植区愈合更快，P<0.001。脱细胞真皮基质与薄自体皮的即刻移植效果良好，晚期结果可接受，且供皮区愈合比标准中厚移植更快。
