皮肤替代物在急性烧伤和烧伤重建手术中的作用：最新综合综述
The Role of Skin Substitutes in Acute Burn and Reconstructive Burn Surgery: An Updated Comprehensive Review.
作者信息
Palackic Alen, Duggan Robert P, Campbell Matthew S, Walters Elliot, Branski Ludwik K, Ayadi Amina El, Wolf Steven E
机构信息
Department of Surgery, Division of Burn and Trauma Surgery, University of Texas Medical Branch, Galveston, Texas.
Department of Surgery, Division of Plastic, Aesthetic and Reconstructive Surgery, Medical University of Graz, Graz, Austria.
出版信息
Semin Plast Surg. 2022 Apr 12;36(1):33-42. doi: 10.1055/s-0042-1743455. eCollection 2022 Feb.
Abstract
Burns disrupt the protective skin barrier with consequent loss of cutaneous temperature regulation, infection prevention, evaporative losses, and other vital functions. Chronically, burns lead to scarring, contractures, pain, and impaired psychosocial well-being. Several skin substitutes are available and replace the skin and partially restore functional outcomes and improve cosmesis. We performed a literature review to update readers on biologic and synthetic skin substitutes to date applied in acute and reconstructive burn surgery. Improvement has been rapid in the development of skin substitutes in the last decade; however, no available skin substitute fulfills criteria as a perfect replacement for damaged skin.
摘要
烧伤会破坏皮肤的保护屏障，进而导致皮肤温度调节功能丧失、无法预防感染、水分蒸发流失以及其他重要功能受损。长期来看，烧伤会导致瘢痕形成、挛缩、疼痛以及心理社会幸福感受损。目前有几种皮肤替代品可供使用，它们能够替代皮肤并部分恢复功能结果，改善外观。我们进行了一项文献综述，旨在向读者介绍迄今为止在急性和重建性烧伤手术中应用的生物和合成皮肤替代品。在过去十年中，皮肤替代品的发展迅速；然而，目前尚无一种皮肤替代品能够完全满足作为受损皮肤完美替代品的标准。
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