Myers R R, Stockard J J
Clin Pharmacol Ther. 1975 Feb;17(2):212-20. doi: 10.1002/cpt1975172212.
Neurologic and electroencephalographic (EEG) examinations were performed every two hours during a case of severe glutethimide intoxication resulting from the acute ingestion of at least 15 grams of glutethimide. Neurologic data were reduced to 10 measurements of brainstem function and plotted as an index that varied cyclically in amplitude during the clinical course. Electroencephalographic data were computer-processed by power spectral methods and related to the brainstem function index. Good positive correlation existed between the frequency and reactivity of EEG activity and the level of brainstem function as reflected in the index. The cyclic and, sometimes, unilateral nature of the clinical findings previously reported in glutethimide coma was confirmed and seen to be reflected in the EEG. The present case also indicates that, in the absence of cerebral ischemia or hypoxemia secondary to cardiopulmonary depression, complete clinical recovery from glutethimide-induced coma is possible no matter how severe the presenting neurologic and EEG signs.
在一例因急性摄入至少15克格鲁米特导致严重格鲁米特中毒的病例中，每两小时进行一次神经系统和脑电图（EEG）检查。神经系统数据被简化为10项脑干功能测量指标，并绘制为一个在临床过程中振幅呈周期性变化的指数。脑电图数据通过功率谱方法进行计算机处理，并与脑干功能指数相关联。脑电图活动的频率和反应性与该指数所反映的脑干功能水平之间存在良好的正相关。先前报道的格鲁米特昏迷临床发现的周期性，有时是单侧性，得到了证实，并在脑电图中得到体现。本病例还表明，在没有继发于心肺抑制的脑缺血或低氧血症的情况下，无论最初的神经系统和脑电图体征多么严重，格鲁米特诱导的昏迷都有可能完全临床恢复。
