Deschamps F J, Guillaumot M, Raux S
Department of Occupational Health, Faculté de Médecine, 51 rue Cognacq-Jay, 51100 Reims-France.
J Occup Environ Med. 2001 Feb;43(2):127-32. doi: 10.1097/00043764-200102000-00011.
The purpose of this study was to examine the effects on the nervous system in enamels-production workers who have low levels of and long exposure to manganese (Mn). The study included 138 Mn-exposed workers and 137 controls who received questionnaires on symptoms, a battery of psychological tests, and assessments of blood concentrations of metal. The exposure levels to airborne Mn concentrations were determined by personal and stationary samplings. The mean duration exposure to Mn was 19.87 years (SD +/- 9). The workers exposed to Mn reported more nonspecific subjective complaints than the control group. No effect of Mn exposure was indicated by the results of any of the neuropsychological tests. The Mn workers did not have higher concentrations of Mn in blood than the controls. Exposures of workers currently working with Mn averaged 57 micrograms/m3 respirable (personal samplings) and 12 g/m3 (stationary samplings). In conclusion, long exposure to low levels of Mn (approximately 200 micrograms/m3), as induced in our study, showed no significant disturbance of neurological performance.
本研究的目的是调查长期低水平接触锰（Mn）的搪瓷生产工人的神经系统所受影响。该研究纳入了138名接触锰的工人和137名对照者，他们接受了关于症状的问卷调查、一系列心理测试以及血液金属浓度评估。通过个人采样和固定采样测定空气中锰浓度的暴露水平。锰的平均暴露时长为19.87年（标准差±9）。与对照组相比，接触锰的工人报告了更多非特异性主观不适。神经心理学测试结果均未显示锰暴露有任何影响。锰作业工人血液中的锰浓度并不高于对照组。目前从事锰作业的工人的平均暴露水平为可吸入锰57微克/立方米（个人采样）和12克/立方米（固定采样）。总之，如我们研究中所诱导的，长期低水平接触锰（约200微克/立方米）未显示出对神经功能有显著干扰。
