Jannotti-Passos L K, Souza C P, Parra J C, Simpson A J
Centro de Pesquisas Rene Rachou, Belo Horizonte, Minas Gerais, Brazil.
J Parasitol. 2001 Feb;87(1):79-82. doi: 10.1645/0022-3395(2001)087[0079:BMDIIT]2.0.CO;2.
The maternal inheritance of mitochondrial DNA (mtDNA) in eukaryotic organisms occurs because of the selective destruction of paternal mtDNA molecules that may be present in the zygote. The elimination of sperm mtDNA is less efficient in interspecific crosses, and biparental inheritance of mtDNA has been observed in a variety of species. Because interspecific crosses are likely to be extremely rare in nature, parental inheritance of mtDNA has been deemed of little relevance to population genetics. The mtDNA of the parasitic trematode Schistosoma mansoni was examined for its utility in addressing epidemiological questions related to the transmission and spread of schistosomiasis. Prior to embarking on such experiments, we sought to confirm the mode of inheritance of this molecule using the highly polymorphic mtDNA minisatellite as a marker. In 3 separate crosses, mtDNA apparently identical to paternal DNA was observed in some individuals of the F2 and F3 generations. These observations thus suggest the intraspecific paternal inheritance of mtDNA across multiple generations in Schistosoma mansoni.
真核生物中线粒体DNA（mtDNA）的母系遗传是由于对合子中可能存在的父本mtDNA分子进行选择性破坏所致。在种间杂交中，精子mtDNA的消除效率较低，并且在多种物种中都观察到了mtDNA的双亲遗传现象。由于种间杂交在自然界中可能极其罕见，因此mtDNA的双亲遗传被认为与群体遗传学关系不大。对寄生性吸虫曼氏血吸虫的mtDNA进行了检测，以评估其在解决与血吸虫病传播和扩散相关的流行病学问题方面的效用。在开展此类实验之前，我们试图使用高度多态性的mtDNA微卫星作为标记来确认该分子的遗传模式。在3次独立杂交中，在F2和F3代的一些个体中观察到mtDNA明显与父本DNA相同。因此，这些观察结果表明曼氏血吸虫中mtDNA在多个世代中存在种内父系遗传。
