Ravindran B
Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research (ICMR), Bhubaneswar-751023, India.
Trends Parasitol. 2001 Feb;17(2):70-3. doi: 10.1016/s1471-4922(00)01835-3.
Immune-dependent growth and development of infectious agents and pathogenesis of disease are increasingly being recognized. It is proposed that the development of filarial larvae to adult stage parasites takes place in an ambiance of inflammatory T helper cell type 1 cytokines in mammalian hosts, and that susceptibility to filarial infections could be governed by the status of macrophage-derived nitric oxide and host ability to produce antibodies to filarial T-independent (carbohydrate) antigens.
免疫依赖的病原体生长发育及疾病发病机制正日益受到认可。有人提出，丝虫幼虫发育为成虫阶段的寄生虫是在哺乳动物宿主中炎性1型辅助性T细胞细胞因子的环境中发生的，并且丝虫感染的易感性可能受巨噬细胞衍生的一氧化氮状态以及宿主产生针对丝虫非依赖T细胞（碳水化合物）抗原的抗体能力的支配。
