Balbay Y, Tikiz H, Baptiste R J, Ayaz S, Saşmaz H, Korkmaz S
Department of Cardiology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey.
Angiology. 2001 Feb;52(2):109-14. doi: 10.1177/000331970105200204.
The changes in serum concentrations of cytokines such as interleukin-1 (IL-1) beta, interleukin-6 (IL-6), tumor necrosis factor (TNF) alpha and a soluble-intercellular adhesion molecule (sICAM-1) has been investigated in patients with stable angina and acute myocardial infarction. Thirty-four patients with stable angina (SA), 15 with acute myocardial infarction (AMI), and 20 subjects in the control (C) group were included in the study. The mean serum concentrations of sICAM-1, IL-1-beta, IL-6, and TNF-alpha differed significantly among the three groups. Serum concentrations of IL-1 beta, sICAM-1, and TNF-alpha were comparable in the AMI and SA groups and higher than those found in the C group (p < 0.001). The serum concentration of IL-6 was more than twice as high in the AMI group as compared to the other two groups (p < 0.001). The mean serum concentrations of IL-1 beta, TNF-alpha, and IL-6 were comparable in the AMI and SA groups and higher than in the C group.
在稳定型心绞痛和急性心肌梗死患者中，研究了白细胞介素-1（IL-1）β、白细胞介素-6（IL-6）、肿瘤坏死因子（TNF）α和可溶性细胞间黏附分子（sICAM-1）等细胞因子的血清浓度变化。本研究纳入了34例稳定型心绞痛（SA）患者、15例急性心肌梗死（AMI）患者和20例对照组（C）受试者。三组中sICAM-1、IL-1-β、IL-6和TNF-α的平均血清浓度差异显著。AMI组和SA组的IL-1β、sICAM-1和TNF-α血清浓度相当，且高于C组（p<0.001）。AMI组的IL-6血清浓度比其他两组高出两倍多（p<0.001）。AMI组和SA组的IL-1β、TNF-α和IL-6平均血清浓度相当，且高于C组。
