de Godoy J M, Batigália F, Braile D M
Department of Cardiology and Vascular Surgery, São José do Rio Preto University School of Medicine, São Paulo, Brazil.
Angiology. 2001 Feb;52(2):127-9. doi: 10.1177/000331970105200206.
The aim of this study was to determine a possible association between recidivist superficial thrombophlebitis and anticardiolipin antibodies. Forty-five patients with two or more episodes of superficial thrombophlebitis in lower limbs (33 women and 12 men with ages ranging from 17 to 60 years, average: 39.8) were studied. The control group was formed by 100 voluntary donors from the blood bank (83 men and 17 women, age range: 21 to 59 years, average: 35.4). Anticardiolipin antibody concentrations were determined by enzyme-linked immunosorbent assay (ELISA). For semiquantitative detection in human sera with use of QUANTA Lite ACA IgG/IgM--INOVA Diagnostic, Inc., and positive values were considered as 15 GPL units/mL and 12.5 MPL units/mL for immunoglobulin G (IgG) and IgM, respectively, as recommended by the test. The Odds Ratio method was chosen for statistical analysis with a confidence interval (CI) of 95%. In 15 patients (33.3%) anticardiolipin antibody positivity was detected, whereas in 12 patients (26.7%) it occurred as immunoglobulin M (IgM) anticardiolipin and in 3 (6.7%) as immunoglobulin G anticardiolipin. In the control group, positivity was found in 7 patients (7%) for those antibodies. Furthermore, the Odds Ratio = 6.64 with CI = 95% and values ranging from 2.48 to 17.82 (p < 0.05) were significant, as well as for IgM/IgG anticardiolipin proportion with Odds Ratio = 5.09, C = 95% and values varying from 1.33 to 19.54 (p < 0.05). The authors conclude that there is a correlation between the presence of anticardiolipin antibodies and recurrent superficial thrombophlebitis.
本研究的目的是确定复发性浅表血栓性静脉炎与抗心磷脂抗体之间可能存在的关联。研究了45例下肢发生两次或更多次浅表血栓性静脉炎的患者（33名女性和12名男性，年龄在17至60岁之间，平均39.8岁）。对照组由血库的100名自愿献血者组成（83名男性和17名女性，年龄范围：21至59岁，平均35.4岁）。采用酶联免疫吸附测定（ELISA）法测定抗心磷脂抗体浓度。使用QUANTA Lite ACA IgG/IgM（INOVA诊断公司）对人血清进行半定量检测，按照该检测推荐，免疫球蛋白G（IgG）和IgM的阳性值分别视为15 GPL单位/毫升和12.5 MPL单位/毫升。采用优势比方法进行统计分析，置信区间（CI）为95%。在15例患者（33.3%）中检测到抗心磷脂抗体阳性，其中12例患者（26.7%）为免疫球蛋白M（IgM）抗心磷脂阳性，3例患者（6.7%）为免疫球蛋白G抗心磷脂阳性。在对照组中，7例患者（7%）检测到这些抗体阳性。此外，优势比=6.64，CI = 95%，值范围为2.48至17.82（p<0.05）具有显著性，IgM/IgG抗心磷脂比例的优势比=5.09，C = 95%，值范围为1.33至19.54（p<0.05）也具有显著性。作者得出结论，抗心磷脂抗体的存在与复发性浅表血栓性静脉炎之间存在相关性。
