Immanuel Suzanna, Giantini Astuti, Dharma Rahajuningsih S
Department of Clinical Pathology, Faculty of Medicine University of Indonesia-Dr. Cipto Mangunkusumo Hospital, Jakarta.
Acta Med Indones. 2005 Oct-Dec;37(4):205-9.
To determine the role of persistent ACA and hyperviscosity as risk factor of ischemic stroke.
A study was conducted on 76 subjects whose age 40 to 70 years. Subjects consisted of 38 patients of post ischemic stroke and 38 controls with diagnosis other than stroke. Fresh blood samples were taken and mixed with EDTA for viscosity examination and serum for ACA IgM and IgG examination. The laboratory examination for persistent ACA IgM and IgG used ELISA method, while viscosity analysis was using viscometer. Statistic analysis used chi-square and multivariate analysis with logistic regression.
In this study we found persistent ACA IgG in 25% of case group , and 2.63% in control group. Multivariate analysis showed persistent ACA IgG as risk factor for ischemic stroke with p < 0.05 and OR 14.11 (CI 95%:1.64;121.11). We found persistent ACA IgM in 2.78% of case group and 5.26% in control group. High blood viscosity was found in 15.79% case group and 10.53% in a control group. Statistical analysis showed no significant difference of viscosity (p = 0.740) and persistent ACA IgM (p = 1.000) between case and control group.
study showed that persistent ACA IgG in stroke ischemic was higher than in control subjects. Blood viscosity examination and persistent ACA IgM did not show significant difference. While persistent ACA IgG with OR 14.11 (CI: 1.64; 121.11) was the risk factor for ischemic stroke. Blood viscosity and persistent ACA IgM were not risk factors for ischemic stroke.
确定持续性抗心磷脂抗体（ACA）和高粘滞血症作为缺血性中风危险因素的作用。
对76名年龄在40至70岁的受试者进行了一项研究。受试者包括38名缺血性中风后患者和38名非中风诊断的对照组。采集新鲜血液样本，与乙二胺四乙酸（EDTA）混合用于粘度检查，血清用于ACA IgM和IgG检查。持续性ACA IgM和IgG的实验室检查采用酶联免疫吸附测定（ELISA）法，而粘度分析则使用粘度计。统计分析采用卡方检验和逻辑回归多变量分析。
在本研究中，我们发现病例组中25%存在持续性ACA IgG，对照组中为2.63%。多变量分析显示，持续性ACA IgG是缺血性中风的危险因素，p < 0.05，比值比（OR）为14.11（95%置信区间：1.64；121.11）。我们发现病例组中2.78%存在持续性ACA IgM，对照组中为5.26%。病例组中15.79%存在高血粘度，对照组中为10.53%。统计分析显示，病例组和对照组之间的粘度（p = 0.740）和持续性ACA IgM（p = 1.000）无显著差异。
研究表明，缺血性中风患者中持续性ACA IgG高于对照组。血液粘度检查和持续性ACA IgM未显示出显著差异。而持续性ACA IgG的OR为14.11（置信区间：1.64；121.11）是缺血性中风的危险因素。血液粘度和持续性ACA IgM不是缺血性中风的危险因素。
