Geyer O, Man O, Weintraub M, Silver D M
Department of Ophthalmology, Carmel Medical Center, Haifa, Israel.
Am J Ophthalmol. 2001 Feb;131(2):198-202. doi: 10.1016/s0002-9394(00)00797-2.
To determine the effect of an acute dose of 0.005% latanoprost on intraocular pressure and pulsatile ocular blood flow in normal eyes.
Nineteen volunteers received a single dose (two drops) of latanoprost 0.005% in one eye and placebo in the fellow control eye, randomized and masked to the observer. Intraocular pressure, perfusion pressure, pulsatile ocular blood flow, and systemic circulatory parameters were measured before and 8 hours after dosing.
The mean (+/- SE) intraocular pressure, perfusion pressure, and pulsatile ocular blood flow before treatment were 17 +/- 1 mm Hg, 46 +/- 3 mm Hg, and 13 +/- 1 microl per second, respectively, in both the treated and control eyes. The mean intraocular pressure reduction was 4.9 and 2.1 mm Hg (28% and 12%) in the treated and fellow eye, respectively. The mean perfusion pressure increase was 5.6 and 2.8 mm Hg (12% and 6%) in the treated and fellow eye, respectively. The mean pulsatile ocular blood flow increase was 2.7 and 0.2 microl per second (20% and 1%) in the treated and fellow eye, respectively. The treated eye change in pulsatile ocular blood flow was not correlated to the change in perfusion pressure. Simultaneous reduction of intraocular pressure and increase or no significant change in pulsatile ocular blood flow occurred in 15 of 19 (79%) of the treated eyes. The systemic blood pressure and pulse rates remained in normal ranges over the 8-hour period.
In this study, topical latanoprost significantly reduces intraocular pressure and increases ocular blood flow in normal eyes 8 hours after dosing. These effects of latanoprost may be beneficial in the management of glaucoma patients.
确定急性剂量的0.005%拉坦前列素对正常眼眼压和搏动性眼血流量的影响。
19名志愿者一只眼接受单剂量（两滴）0.005%拉坦前列素，另一只对照眼接受安慰剂，随机分组且观察者设盲。给药前及给药后8小时测量眼压、灌注压、搏动性眼血流量和全身循环参数。
治疗眼和对照眼治疗前眼压、灌注压和搏动性眼血流量的平均值（±标准误）分别为17±1 mmHg、46±3 mmHg和13±1微升/秒。治疗眼和对侧眼的平均眼压降低分别为4.9和2.1 mmHg（28%和12%）。治疗眼和对侧眼的平均灌注压升高分别为5.6和2.8 mmHg（12%和6%）。治疗眼和对侧眼的平均搏动性眼血流量增加分别为2.7和0.2微升/秒（20%和1%）。治疗眼搏动性眼血流量的变化与灌注压的变化无关。19只治疗眼中有15只（79%）同时出现眼压降低和搏动性眼血流量增加或无显著变化。8小时内全身血压和脉搏率保持在正常范围内。
在本研究中，局部应用拉坦前列素在给药8小时后可显著降低正常眼的眼压并增加眼血流量。拉坦前列素的这些作用可能对青光眼患者的治疗有益。
