Honavar S G, Shields J A, Shields C L, Demirci H, Ehya H
Oncology Service, Wills Eye Hospital, Thomas Jefferson University, 900 Walnut St., Philadelphia, PA 19107, USA.
Am J Ophthalmol. 2001 Feb;131(2):277-8. doi: 10.1016/s0002-9394(00)00706-6.
To report a case of an extramedullary plasmacytoma confined to the choroid.
Interventional case report with cytopathologic correlation.
A 76-year-old asymptomatic woman presented with 2 globular orange and amelanotic choroidal lesions in the right eye. Fine needle aspiration biopsy of one of the choroidal lesions followed by immunocytochemical studies revealed monoclonal plasma cells, diagnostic of plasmacytoma. Systemic evaluation was negative, except for increased serum gamma globulin with immunoglobulin kappa spike on electrophoresis. The patient was managed by ocular external beam radiotherapy. At 9 years follow-up, she was free of local disease and never developed multiple myeloma.
Extramedullary plasmacytoma confined to the choroid is rare. It may present simulating other common amelanotic choroidal lesions. Fine needle aspiration biopsy and proper systemic evaluation are critical in establishing the diagnosis.
报告一例局限于脉络膜的髓外浆细胞瘤病例。
伴有细胞病理学相关性的介入病例报告。
一名76岁无症状女性右眼出现2个球形橙色无色素脉络膜病变。对其中一个脉络膜病变进行细针穿刺活检并进行免疫细胞化学研究，发现单克隆浆细胞，诊断为浆细胞瘤。全身评估为阴性，仅电泳显示血清γ球蛋白升高且有免疫球蛋白κ峰。该患者接受了眼部外照射放疗。随访9年，她无局部疾病，也从未发展为多发性骨髓瘤。
局限于脉络膜的髓外浆细胞瘤罕见。它可能表现类似其他常见的无色素脉络膜病变。细针穿刺活检和适当的全身评估对确立诊断至关重要。
