Ayton Tom, Cherepanoff Svetlana, Gottlieb David, Sewell William A, Smith Sandy, Hooper Claire
University of New South Wales, Sydney, Australia.
St Vincent's Hospital, Sydney, Australia.
BMC Ophthalmol. 2021 Jan 30;21(1):66. doi: 10.1186/s12886-021-01822-9.
Solitary extramedullary plasmacytoma (SEP) is a localised proliferation of monoclonal plasma cells involving soft tissue with no or minimal bone marrow involvement and no other systemic evidence of multiple myeloma. Intraocular involvement is exceedingly rare.
We report a 78-year-old man who was referred with glaucoma in the right eye. He subsequently developed anterior chamber (AC) inflammation and refractory glaucoma then dense vitritis. A vitrectomy was performed with the biopsy revealing numerous plasma cells with atypical findings. In conjunction with the flow cytometry results, and a systemic work up excluding multiple myeloma, a diagnosis of SEP was made. The patient was treated with ocular external beam radiotherapy with resolution of the intraocular inflammation and control of the intraocular pressure. He remains well with no local recurrence and no development of multiple myeloma over a follow up period of 2.5 years.
This is the first case report of SEP presenting as intraocular inflammation without a uveal tract mass.
孤立性髓外浆细胞瘤（SEP）是一种单克隆浆细胞的局限性增殖，累及软组织，无或仅有极少的骨髓受累，且无其他多发性骨髓瘤的全身证据。眼内受累极为罕见。
我们报告一名78岁男性，因右眼青光眼前来就诊。随后他出现前房炎症和难治性青光眼，继而出现严重玻璃体炎。进行了玻璃体切除术，活检显示有大量具有非典型表现的浆细胞。结合流式细胞术结果以及排除多发性骨髓瘤的全身检查，诊断为SEP。患者接受了眼部外照射放疗，眼内炎症消退，眼压得到控制。在2.5年的随访期内，他情况良好，无局部复发，也未发展为多发性骨髓瘤。
这是首例SEP表现为无葡萄膜肿物的眼内炎症的病例报告。
