Cumano A, Godin I
Unité du Développement des Lymphocytes, Institut Pasteur, 25 Rue du Dr Roux, 75724, Paris, France.
Curr Opin Immunol. 2001 Apr;13(2):166-71. doi: 10.1016/s0952-7915(00)00200-4.
Significant progress has been made towards a better understanding of the establishment of hematopoiesis in the embryo. Hematopoietic precursors have been shown to arise independently in the yolk sac and in the intra-embryonic mesoderm. From the combined analysis of differentiation potentials, expression patterns and mutant phenotypes, a picture has emerged: definitive hematopoietic precursors are transiently generated in a specific environment close to the endothelium of the main arteries.
在更好地理解胚胎造血过程的建立方面已经取得了重大进展。造血前体细胞已被证明在卵黄囊和胚胎内中胚层中独立产生。通过对分化潜能、表达模式和突变体表型的综合分析，一幅图景浮现出来：确定的造血前体细胞在靠近主动脉内皮的特定环境中短暂产生。
